Search Results

Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkappaB activity

Chronic inflammation, as seen in conditions such as rheumatoid arthritis (RA) and Crohn's disease, is in part driven by discordant production of inflammatory cytokines such as tumour necrosis factor alpha (TNF) and interleukin (IL)-6. Tyrosine kinase...

Authors: Palmer CD, Mutch BE, Workman S, McDaid JP, Horwood NJ, Foxwell BM

Nucleic acid therapeutics for hematologic malignancies--theoretical considerations

Our work is motivated by the belief that RNA targeted gene silencing agents can be developed into effective drugs for treating hematologic malignancies. In many experimental systems, antisense nucleic acids of various composition, including antisense...

Authors: Opalinska JB, Kalota A, Chattopadhyaya J, Damha M, Gewirtz AM

Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin

Methylglyoxal (MGO) is an alpha-dicarbonyl compound produced from triose phosphate intermediates of glycolysis. It reacts rapidly with proteins to produce advanced glycation products. We have studied the effect of MGO modification of fibronectin on...

Authors: Nagaraj RH, Oya-Ito T, Bhat M, Liu B

Molecular Interactions between T Cells and Fibroblast-Like Synoviocytes. Role of Membrane Tumor Necrosis Factor-alpha on Cytokine-Activated T Cells

The mechanism of fibroblast-like synoviocyte (FLS) transformation into an inflammatory phenotype in rheumatoid arthritis (RA) is not fully understood. FLS interactions with invading leukocytes, particularly T cells, are thought to be a critical...

Authors: Tran CN, Lundy SK, White PT, Endres JL, Motyl CD, Gupta R, Wilke CM, Shelden EA, Chung KC, Urquhart...

Syndecan-4 Mediates the Coinhibitory Function of DC-HIL on T Cell Activation

Receptor-ligand interactions between APCs and T cells determine whether stimulation of the latter leads to activation or inhibition. Previously, we showed that dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand (DC-HIL)...

Authors: Chung JS, Dougherty I, Cruz PD Jr, Ariizumi K

Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death

At present, the signaling pathways controlling reactive nitrogen species (RNS)-induced non-apoptotic cell death are relatively less understood. In this work, various RNS donors are found to induce caspase-independent non-apoptotic cell death in mouse...

Authors: Wu YT, Zhang S, Kim YS, Tan HL, Whiteman M, Ong CN, Liu ZG, Ichijo H, Shen HM

Macrophages from 11beta-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice Exhibit an Increased Sensitivity to Lipopolysaccharide Stimulation Due to TGF-beta-Mediated Up-Regulation of SHIP1 Expression

11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) performs end-organ metabolism of glucocorticoids (GCs) by catalyzing the conversion of C(11)-keto-GCs to C(11)-hydroxy-GCs, thereby generating activating ligands for the GC receptor. In this...

Authors: Zhang TY, Daynes RA

SST Peer Reviewed

The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription

When the orphan nuclear receptors TR2 and TR4, the DNA-binding subunits of the DRED repressor complex, are forcibly expressed in erythroid cells of transgenic mice, embryos exhibit a transient mid-gestational anemia as a consequence of a reduction in...

Authors: Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD

Chemical genetic screening identifies tricyclic compounds that decrease cellular melanin content

A screen of a library of 2,000 drugs and natural products in murine melanocytes identified 10 tricyclic antidepressants (TCAs) as compounds that potently decreased intracellular melanin content. The rank order of potency of these compounds for...

Authors: Ni-Komatsu L, Orlow SJ

Cutting Edge: Atypical PKCs Regulate T Lymphocyte Polarity and Scanning Behavior

Leukocyte locomotion is a polarized process with diverse regulatory assemblies segregating along an anterior-posterior axis that defines two regions within the cell, the leading edge and the uropod. However, the mechanisms that generate T cell...

Authors: Real E, Faure S, Donnadieu E, Delon J

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