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Elf-1 Binds to GGAA Elements on the FcR Promoter and Represses Its Expression

The Fc receptor (FcR) gamma-chain has been shown to be up-regulated in T cells when the TCR zeta-chain is decreased. We demonstrate that Elf-1, but not other Ets family transcription factors, bind to a cluster of GGAA sites located within the 200 bp...

Authors: Juang YT, Sumibcay L, Tolnay M, Wang Y, Kyttaris VC, Tsokos GC

Myosin Va controls oligodendrocyte morphogenesis and myelination

A product of myosin Va mutations, Griscelli's syndrome type 1 (GS1) is characterized by several neurologic deficits including quadraparesis, mental retardation, and seizures. Although multiple studies have not clearly established a cause for the...

Authors: Sloane JA, Vartanian TK

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

Eph receptors and ephrins have been implicated in a variety of cellular processes, including morphology and motility, because of their ability to modulate intricate signaling networks. Here we show that the phosphotyrosine binding (PTB)...

Authors: Shin J, Gu C, Park E, Park S

Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2

Scaffolding proteins including kinase suppressor of Ras-1 (KSR1) determine specificity of signaling by extracellular signal-regulated kinase 1/2 (ERK1/2), enabling it to couple diverse extracellular stimuli to various cellular responses. The...

Authors: Szatmari E, Kalita KB, Kharebava G, Hetman M

Myeloperoxidase Is a Key Regulator of Oxidative Stress Mediated Apoptosis in Myeloid Leukemic Cells

PURPOSE: We reported previously that reactive oxygen species (ROS) are key mediators of apoptosis induced by a polyphenol, (-)-epigallocatechin-3-gallate (EGCG), in myeloid leukemic cells. This study aimed to further examine the mechanism of...

Authors: Nakazato T, Sagawa M, Yamato K, Xian M, Yamamoto T, Suematsu M, Ikeda Y, Kizaki M

Target cell APOBEC3C can induce limited G-to-A mutation in HIV-1

The evolutionary success of primate lentiviruses reflects their high capacity to mutate and adapt to new host species, immune responses within individual hosts, and, in recent years, antiviral drugs. APOBEC3G (A3G) and APOBEC3F (A3F) are host cell...

Authors: Bourara K, Liegler TJ, Grant RM

The Nuclear Matrix Protein, NRP/B, Enhances Nrf2-Mediated Oxidative Stress Responses in Breast Cancer Cells

The transcription factor NF-E2-related factor 2 (Nrf2) translocates into the nucleus and activates phase II genes encoding detoxification enzymes and antioxidant proteins, resulting in the protection of cells from oxidative insults. However, the...

Authors: Seng S, Avraham HK, Jiang S, Yang S, Sekine M, Kimelman N, Li H, Avraham S

Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1

We have previously shown that long-term treatment of airway smooth muscle (ASM) cells with a combination of TNFalpha and IFNgamma impaired steroid anti-inflammatory action through the upregulation of glucocorticoid receptor beta isoform (GRbeta) (Mol...

Authors: Tliba O, Damera G, Banerjee A, Gu S, Baidouri H, Keslacy S, Amrani Y

Reciprocal regulation of p63 by C/EBPdelta in human keratinocytes

BACKGROUND: Genetic experiments have clarified that p63 is a key transcription factor governing the establishment and maintenance of multilayered epithelia. Key to our understanding of p63 strategy is the identification of target genes. We perfomed...

Authors: Borrelli S, Testoni B, Callari M, Alotto D, Castagnoli C, Romano RA, Sinha S, Vigano AM, Mantovani...

Differential Activities of Glucocorticoid-induced Leucine Zipper Protein Isoforms

Glucocorticoid-induced leucine zipper protein (GILZ) is expressed in both epithelial and immune tissues and modulates a variety of cellular functions, including proliferation and epithelial sodium channel (ENaC) activity. A number of reports have...

Authors: Soundararajan R, Wang J, Melters DP, Pearce D

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