Search Results

Kalirin/Trio rho Guanine nucleotide exchange factors regulate a novel step in secretory granule maturation

The molecular mechanisms involved in the maturation of secretory granules, organelles that store hormones and neuropeptides, are poorly understood. As granule content proteins are processed, the composition of granule membranes changes, yielding...

Authors: Ferraro F, Ma XM, Sobota JA, Eipper BA, Mains RE

Zap70 signaling pathway mediates glucocorticoid receptor-dependent transcriptional activation: role in the regulation of annexin 1 expression in T cells

We have recently shown that Zap70 is important in retinoid receptor-dependent transactivation in T lymphocytes. We report that Zap70 signaling is also essential in dexamethasone-inducible glucocorticoid receptor (GR)-mediated transactivation in T...

Authors: Ishaq M, Degray G, Mou K, Aguilera A, Yang J, Lempicki RA, Hazen A, Natarajan V

Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway

Previous studies have shown that mitofusin 2 (Mfn-2) (or hyperplasia suppressor gene [HSG]) inhibits vascular smooth muscle cell (VSMC) proliferation. Here, we demonstrate that Mfn-2 is a primary determinant of VSMC apoptosis. First, oxidative stress...

Authors: Guo X, Chen KH, Guo Y, Liao H, Tang J, Xiao RP

Old World Arenavirus Infection Interferes with the Expression of Functional alpha-Dystroglycan in the Host Cell

alpha-Dystroglycan (alpha-DG) is an important cellular receptor for extracellular matrix (ECM) proteins as well as the Old World arenaviruses lymphocytic choriomeningitis virus (LCMV) and the human pathogenic Lassa fever virus (LFV). Specific...

Authors: Rojek JM, Campbell KP, Oldstone MB, Kunz S

SST Peer Reviewed

Elf-1 Binds to GGAA Elements on the FcR Promoter and Represses Its Expression

The Fc receptor (FcR) gamma-chain has been shown to be up-regulated in T cells when the TCR zeta-chain is decreased. We demonstrate that Elf-1, but not other Ets family transcription factors, bind to a cluster of GGAA sites located within the 200 bp...

Authors: Juang YT, Sumibcay L, Tolnay M, Wang Y, Kyttaris VC, Tsokos GC

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

Eph receptors and ephrins have been implicated in a variety of cellular processes, including morphology and motility, because of their ability to modulate intricate signaling networks. Here we show that the phosphotyrosine binding (PTB)...

Authors: Shin J, Gu C, Park E, Park S

G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells

The effectiveness of IFN-alpha2b for human multiple myeloma has been variable. TRAIL has been proposed to mediate IFN-alpha2b apoptosis in myeloma. In this study we assessed the effects of IFN-alpha2b signaling on the apoptotic activity of TRAIL and...

Authors: Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC

Myeloperoxidase Is a Key Regulator of Oxidative Stress Mediated Apoptosis in Myeloid Leukemic Cells

PURPOSE: We reported previously that reactive oxygen species (ROS) are key mediators of apoptosis induced by a polyphenol, (-)-epigallocatechin-3-gallate (EGCG), in myeloid leukemic cells. This study aimed to further examine the mechanism of...

Authors: Nakazato T, Sagawa M, Yamato K, Xian M, Yamamoto T, Suematsu M, Ikeda Y, Kizaki M

Refined Characterization of the Expression and Stability of the SMN Gene Products

Spinal muscular atrophy (SMA) is characterized by degeneration of lower motor neurons and caused by mutations of the SMN1 gene. SMN1 is duplicated in a homologous gene called SMN2, which remains present in patients. SMN has an essential role in RNA...

Authors: Vitte J, Fassier C, Tiziano FD, Dalard C, Soave S, Roblot N, Brahe C, Saugier-Veber P, Bonnefont JP,...

Involvement of Rho kinase in endothelial barrier maintenance

OBJECTIVE: Rho kinase mediates vascular leakage caused by many vasoactive agents including thrombin. Enhanced Rho kinase activity induces endothelial barrier dysfunction by a contractile mechanism via inactivation of Myosin Phosphatase (MP). Here, we...

Authors: van Nieuw Amerongen GP, Beckers CM, Achekar ID, Zeeman S, Musters RJ, van Hinsbergh VW

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin