Search Results

Neurabin-I is phosphorylated by cdk5: implications for neuronal morphogenesis and cortical migration

The correct morphology and migration of neurons, which is essential for the normal development of the nervous system, is enabled by the regulation of their cytoskeletal elements. We reveal that Neurabin-I, a neuronal-specific F-actin-binding protein,...

Authors: Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M

PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development

In our previous study, we identified RICS, a novel beta-catenin-interacting protein with the GAP activity toward Cdc42 and Rac1, and found that RICS plays an important role in the regulation of neural functions, including postsynaptic NMDA signaling...

Authors: Hayashi T, Okabe T, Nasu-Nishimura Y, Sakaue F, Ohwada S, Matsuura K, Akiyama T, Nakamura T

The Atg5 Atg12 conjugate associates with innate antiviral immune responses

Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the Atg5-Atg12 conjugate, a key regulator of the autophagic process, plays an important role in...

Authors: Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki...

A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane

The type II inner nuclear membrane protein emerin is a component of the LINC complex that connects the nuclear lamina to the actin cytoskeleton. In emerin-null or -deficient human dermal fibroblasts we find that the centrosome is detached from the...

Authors: Salpingidou G, Smertenko A, Hausmanowa-Petrucewicz I, Hussey PJ, Hutchison CJ

Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma

OBJECTIVE: Previously published studies have demonstrated that a majority of systemic sclerosis (SSc) fibroblasts exhibit elevated levels of transforming growth factor beta type I receptor (TGFbetaRI). An experimental model that recapitulates this...

Authors: Pannu J, Gardner H, Shearstone JR, Smith E, Trojanowska M

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed-lineage K3

Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase member that activates the c-Jun N-terminal kinase (JNK) pathway. Aberrant activation of MLK3 has been implicated in neurodegenerative diseases. Similarly, glycogen...

Authors: Mishra R, Barthwal MK, Sondarva G, Rana B, Wong L, Chatterjee M, Woodgett JR, Rana A

Snapin, a new regulator of receptor signaling, augments alpha 1A-adrenoceptor-operated calcium influx through TRPC6

Activation of G(q)-protein-coupled receptors, including the alpha(1A)-adrenoceptor (alpha(1A)-AR), causes a sustained Ca(2+) influx via receptor-operated Ca(2+) (ROC) channels, following the transient release of intracellular Ca(2+). Transient...

Authors: Suzuki F, Morishima S, Tanaka T, Muramatsu I

SST Peer Reviewed

PDGF Synergistically Enhances IFN--Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia

There is increasing cumulative evidence that activated mononuclear phagocytes (macrophages/microglia) releasing inflammatory mediators in the CNS are a better correlate of HIV-associated dementia (HAD) than the actual viral load in the brain. Earlier...

Authors: Dhillon NK, Peng F, Ransohoff RM, Buch S

Compound Heterozygosity for Mutations in LMNA in a Patient with a Myopathic and Lipodystrophic Mandibuloacral Dysplasia Type A Phenotype

Context: Mandibuloacral dysplasia type A [MADA; OMIM#248370] is a rare progeroid syndrome characterised by dysmorphic craniofacial and skeletal features, lipodystrophy and metabolic complications. Most of Italian patients carry the same homozygous...

Authors: Lombardi F, Gullotta F, Columbaro M, Filareto A, D'Adamo M, Vielle A, Guglielmi V, Nardone AM,...

T Cells Express 7-Nicotinic Acetylcholine Receptor Subunits That Require a Functional TCR and Leukocyte-Specific Protein Tyrosine Kinase for Nicotine-Induced Ca2+ Response

Acute and chronic effects of nicotine on the immune system are usually opposite; acute treatment stimulates while chronic nicotine suppresses immune and inflammatory responses. Nicotine acutely raises intracellular calcium ([Ca(2+)](i)) in T cells,...

Authors: Razani-Boroujerdi S, Boyd RT, DÜ¡vila-GarcÜa MI, Nandi JS, Mishra NC, Singh SP, Pena-Philippides...

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