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Contributions of galectin-3 and -9 to epithelial cell adhesion analysed by single cell force spectroscopy

Galectins are widely expressed in epithelial tissues and have been implicated in a variety of cellular processes, including adhesion and polarization. Here we studied the contributions of galectins in cell adhesion and cyst formation of Madin-Darby...
Authors: Friedrichs J, Torkko JM, Helenius J, Teräväinen TP, Füllekrug J, Muller DJ, Simons K, Manninen A

Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase

Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology- and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies demonstrated that STAP-2...
Authors: Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A,...

Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury

Loss of mitochondrial membrane integrity and release of apoptogenic factors are a key step in the signaling cascade leading to neuronal cell death in various neurological disorders, including ischemic injury. Emerging evidence has suggested that the...
Authors: Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J

Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans

Keratan sulfate glycosaminoglycans are among the most abundant carbohydrate components of the cornea and are suggested to play an important role in maintaining corneal extracellular matrix structure. Keratan sulfate carbohydrate chains consist of...
Authors: Kitayama K, Hayashida Y, Nishida K, Akama TO

Microbial Products Stimulate Human Toll-like Receptor 2 Expression through Histone Modification Surrounding a Proximal NF-B-binding Site

Previous studies have yielded conflicting results regarding the ability of microbial products to activate TLR2 gene expression in human monocytes. In this study, we found that TLR2 mRNA was rapidly up-regulated in human monocytes treated with TLR2...
Authors: Johnson CM, Tapping RI

Molt16

T cell lymphoma, Leukemic T cell line

NSC34

spinal cord neuroblastoma

IHH

immortalized hepatocyte

IM9

B-lymphoblastoid cells from the bone marrow of a woman with multiple myeloma but cells appear to be 'EBV+ B-lymphoblastoid cells' rather than myeloma-derived cells (see also Pellat-Deceunynk et al., Blood 86: 4001-4002, 1995)

mIMCD3

kidney, medulla; collecting duct; SV40 transformed
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