Search Results

Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses

Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia. Host control of Mycobacterium tuberculosis is dependent on the activation of CD4(+) T cells secreting IFN-gamma and their...

Authors: Wozniak TM, Ryan AA, Britton WJ

Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells

The B-cell chronic lymphocytic leukemia (CLL)/lymphoma 11B gene (BCL11B) encodes a Krüppel-like zinc-finger protein, which plays a crucial role in thymopoiesis and has been associated with hematopoietic malignancies. It was hypothesized that BCL11B...

Authors: Grabarczyk P, Przybylski GK, Depke M, Volker U, Bahr J, Assmus K, Broker BM, Walther R, Schmidt CA

Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis

Senescence is thought to be an inherent tumor-suppressive mechanism. In the process of identifying senescence-associated genes, we found significant suppression of the ets homologous factor (EHF) in cancer cells in a state of DNA damage-induced...

Authors: Park C, Lee I, Kang WK

Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

Although glucocorticoids play an important role in the treatment of multiple myeloma, some patients do not respond or develop resistance. The glucocorticoid receptor (GR), a single gene, mediates the effects of glucocorticoids. Using a model system...

Authors: Sanchez-Vega B, Krett N, Rosen ST, Gandhi V

Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway

MafA is a basic leucine zipper transcription factor that regulates gene expression in both the neuroretina and pancreas. Within the pancreas, MafA is exclusively expressed in the beta cells and is involved in insulin gene transcription, insulin...

Authors: Vanderford NL, Andrali SS, Ozcan S

Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis

OBJECTIVE: The receptor for advanced glycation end products (RAGE) binds multiple ligands, including S100 proteins, high mobility group box chromosomal protein 1 (HMGB-1), and AGEs, all of which are present in articular cartilage. Stimulation of RAGE...

Authors: Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD

Cell divisions are required for L1 retrotransposition

LINE-1 (L1) retrotransposons comprise a large fraction of genomic DNAs of many organisms. Many L1 elements are active and may generate potentially deleterious mutations by inserting into genes, yet little is known about the control of...

Authors: Shi X, Seluanov A, Gorbunova V

Glycosylation mediates upregulation of a potent antiangiogenic and proatherogenic protein, Thrombospondin-1, by glucose in vascular smooth muscle cells

Accelerated development of atherosclerotic lesions remains the most frequent and dangerous complication of diabetes, accounting for 80% of deaths among diabetics. However, our understanding of the pathways mediating glucose-induced gene expression in...

Authors: Raman P, Krukovets I, Marinic TE, Bornstein P, Stenina OI

Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts

Elastin synthesis is essential for lung development and postnatal maturation as well as for repair following injury. Using human embryonic lung fibroblasts that express undetectable levels of elastin as assessed by Northern analyses, we found that...

Authors: Kuang PP, Zhang XH, Rich CB, Foster JA, Subramanian M, Goldstein RH

Modification of the Pig CFTR Gene Mediated by Small Fragment Homologous Replacement

The generation of a pig model of cystic fibrosis (CF) is a multistep process. Initial steps in this process involved the design and cloning of a small DNA fragment (SDF) or large oligodeoxynucleotide (LODN) that contains the F508del mutation and a...

Authors: Maurisse R, Cheung J, Widdicombe J, Gruenert DC

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