Search Results

Glioblastoma-Derived Exosomes as Nanopharmaceutics for Improved Glioma Treatment

The use of cancer-derived exosomes has been studied in several cancer types, but the cancer-targeting efficacy of glioma-derived exosomes has not been investigated in depth for malignant glioblastoma (GBM) cells. In this study, exosomes were derived...

Authors: Lee H, Bae K, Baek AR, Kwon EB, Kim YH, Nam SW, Lee GH, Chang Y

SST Peer Reviewed

Naïve Primary Mouse CD8+ T Cells Retain In Vivo Immune Responsiveness After Electroporation-Based CRISPR/Cas9 Genetic Engineering

CRISPR/Cas9 technology has revolutionized genetic engineering of primary cells. Although its use is gaining momentum in studies on CD8+ T cell biology, it remains elusive to what extent CRISPR/Cas9 affects in vivo function of...

Authors: Pfenninger P, Yerly L, Abe J

SST Peer Reviewed

The Inhibitory Receptor Siglec-8 Interacts With FceRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation

Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in...

Authors: Korver W, Wong A, Gebremeskel S, Negri GL, Schanin J, Chang K, Leung J, Benet Z, Luu T, Brock EC,...

A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes

Multiple complex intracellular cascades contributing to Hunter syndrome (mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the past years. However, the hierarchy of early cellular abnormalities leading to irreversible...

Authors: Badenetti L, Manzoli R, Trevisan M, D'Avanzo F, Tomanin R, Moro E.

SST Peer Reviewed

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Background & aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease. Owing to limited available treatment options, novel pre-clinical models for target selection and drug...

Authors: Yun Kwon , Pascal Gottmann , Surui Wang , Joel Tissink , Karsten Motzler , Revathi Sekar , Wiebke...

Engineered extracellular matrices with controlled mechanics modulate renal proximal tubular cell epithelialization

Acute kidney injury (AKI) is common and associated with significant morbidity and mortality. Recovery from many forms of AKI involves the proliferation of renal proximal tubular epithelial cells (RPTECs), but the influence of the microenvironment in...

Authors: Jeffrey A Beamish , Evan Chen , Andrew J Putnam

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in HSCs

Background and aims: Fibrosis is the common end point for all forms of chronic liver injury, and the progression of fibrosis leads to the development of end-stage liver disease. Activation of HSCs and their transdifferentiation into...

Authors: Cheng Sun , Chan Zhou , Kaveh Daneshvar , Amel Ben Saad , Arcadia J Kratkiewicz , Benjamin J...

Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition

The proximal tubule plays an important role in the kidney and is a major site of drug interaction and toxicity. Analysis of kidney toxicity via in vitro assays is challenging, because only a few assays that reflect functions of drug transporters in...

Authors: Naoki Ishiguro , Etsushi Takahashi , Hiroshi Arakawa , Asami Saito , Fumihiko Kitagawa , Masayuki...

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

The adoption of a new technology into basic research, and industrial and clinical settings requires rigorous testing to build confidence in the reproducibility, reliability, robustness, and relevance of these models. Tissue chips are promising new...

Authors: Courtney Sakolish , Elijah J Weber , Edward J Kelly , Jonathan Himmelfarb , Roula Mouneimne , Fabian...

Uncovering the mechanism of troglitazone-mediated idiosyncratic drug-induced liver injury with individual-centric models

Idiosyncratic drug-induced liver injury is a rare and unpredictable event. Deciphering its initiating-mechanism is a hard task as its occurrence is individual dependent. Thus, studies that utilize models that are not individual-centric might drive to...

Authors: Salomé Roux , Sara Cherradi , Hong Tuan Duong

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Glioblastoma-Derived Exosomes as Nanopharmaceutics for Improved Glioma Treatment

Naïve Primary Mouse CD8+ T Cells Retain In Vivo Immune Responsiveness After Electroporation-Based CRISPR/Cas9 Genetic Engineering

The Inhibitory Receptor Siglec-8 Interacts With FceRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation

A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Engineered extracellular matrices with controlled mechanics modulate renal proximal tubular cell epithelialization

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in HSCs

Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

Uncovering the mechanism of troglitazone-mediated idiosyncratic drug-induced liver injury with individual-centric models