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Angiotensin II-Mediated Protein Kinase D Activation Stimulates Aldosterone and Cortisol Secretion in H295R Human Adrenocortical Cells

Protein kinases are important mediators in intracellular signaling. Angiotensin II is the most important modulator of adrenal zona glomerulosa cell physiology. Angiotensin II regulates steroidogenesis and proliferation among many other metabolic...

Authors: Romero DG, Welsh BL, Gomez-Sanchez EP, Yanes LL, Rilli S, Gomez-Sanchez CE

Regulation of dendritic cell differentiation by bone marrow stroma via different Notch ligands

Notch is a major factor mediating interaction between hematopoietic progenitor cells (HPCs) and bone marrow stroma (BMS). However its contribution to dendritic cell (DC) differentiation is controversial. We found that main Notch ligands Delta-1 and...

Authors: Cheng P, Nefedova Y, Corzo CA, Gabrilovich DI

Evidence for the multimeric structure of Ferroportin

Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease. Previously, we demonstrated that Fpn is a multimer and that mutations in Fpn are dominant negative....

Authors: De Domenico I, Ward DM, Musci G, Kaplan J

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

The unfolded protein response (UPR) is an evolutionarily conserved mechanism by which all eukaryotic cells adapt to the accumulation of unfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring kinase 1 (IRE1) and PKR-related ER kinase...

Authors: Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, Kaufman RJ

Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the isoform does not play a preferential role

CTLs kill virus-infected, tumor, and transplanted targets via secretion of lytic agents including perforin and granzymes. Knowledge of the signals controlling this important process remains vague. We have tested the idea that protein kinase C...

Authors: Grybko MJ, Pores-Fernando AT, Wurth GA, Zweifach A

Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease

Though Abl inhibitors are often successful therapies for the initial stages of chronic myelogenous leukemia (CML), refractory cases highlight the need for novel molecular insights. We demonstrate that mice deficient in the enzyme 12/15-lipoxygenase...

Authors: Middleton MK, Zukas AM, Rubinstein T, Jacob M, Zhu P, Zhao L, Blair I, Pure E

Stable Over-Expression of Human Macrophage Cholesteryl Ester Hydrolase (CEH) Results in Enhanced Free Cholesterol Efflux from Human THP1-macrophages

Reduction of the lipid burden of atherosclerotic lesion-associated macrophage foam cells is a logical strategy to reduce the plaque volume. Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of...

Authors: Zhao B, Song J, St Clair R, Ghosh S

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

Adaptor proteins positively or negatively regulate the T cell receptor for antigen (TCR) signaling cascade. We report that after TCR stimulation, the inhibitory adaptor downstream of kinase (Dok)-2 and its homologue Dok-1 are involved in a...

Authors: Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F

Activated c-Jun N-terminal kinase is required for axon formation

A critical transition in neuron development is formation of the axon, which establishes the polarized structure of the neuron that underlies its entire input and output capabilities. The morphological events that occur during axonogenesis have long...

Authors: Oliva AA Jr, Atkins CM, Copenagle L, Banker GA

NF-kappaB is required for STAT-4 expression during dendritic cell maturation

The transcription factor STAT-4 plays a pivotal role in the IL-12-mediated development of naive CD4(+) T cells into the Th1 phenotype. Initially thought to be restricted to the lymphoid lineage, STAT-4 was subsequently shown to be expressed in the...

Authors: Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM

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