Search Results

Can plate dilutions schemes be transferred to WinKQCL™ Software if contained in a LIMS?

Yes, this information can be pulled from a LIMS if available. For example, an export created in CSV can be exported back into LIMS.

Is it possible to automate the PyroTec Pro standard dilutions?

The standard endotoxin dilutions are created by the system based on what is specified in the WinKQCL™ Software Template specific for that assay. The PyroTec™ PRO System can dynamically create the dilution scheme in the WinKQCL™ Software.The system...

Does the reported Log4j vulnerability threat affect our WinKQCL software (Catalog # 25-611E)?

Thank you for using Lonza Endotoxin Detection Products.Lonza has been providing endotoxin detection products and services since the 1970s, leading the way in innovation of products, methods and software.Our dedicated WinKQCL software is on the market...

Can you provide more information on the PyroTec Pro validation of endotoxin standards made using pipetting vs. vortexing?

The only manual step required is for the analyst to perform the initial reconstitution and vortex the initial stock CSE (or RSE) solution prior to running the assay. The robot prepares the standard curve. As we do not place a vortex mixer on the...

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

BACKGROUND: Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (steel mills and associated...

Authors: Thomson EM1, Breznan D2, Karthikeyan S3, MacKinnon-Roy C4, Charland JP5, Dabek-Zlotorzynska E6, Celo...

Endotoxin recovery using limulus amebocyte lysate (LAL) assay.

A phenomenon initially reported by Chen and Vinther in 2013 [1], and now commonly referred to as low endotoxin recovery (LER), has prompted the Food and Drug Administration (FDA) to request specific data demonstrating the capability of the LAL BET...

Authors: Bolden JS, Warburton RE, Phelan R, Murphy M, Smith KR, De Felippis MR, Chen D.

SST Peer Reviewed

Masking of endotoxin in surfactant samples: Effects on Limulus-based detection systems.

Over the last few decades Limulus Amebocyte Lysate (LAL) has been the most sensitive method for the detection of endotoxins (Lipopolysaccharides) and is well accepted in a broad field of applications. Recently, Low Endotoxin Recovery (LER) in...

Authors: Reich J1, Lang P2, Grallert H3, Motschmann H4

SST Peer Reviewed

Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform

Autologous cell-based therapeutics have gained increasing attention in recent years because of their efficacy at treating diseases with limited therapeutic options. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical success in...

Authors: Trainor N, Purpura KA, Middleton K, Fargo K, Hails L, Vicentini-Hogan M, McRobie C, Daniels R,...

SST Peer Reviewed

The effect of chitin size, shape, source and purification method on immune recognition.

The animal immune response to chitin is not well understood and needs to be investigated further. However, this is a challenging topic to study because of the technical difficulties in purifying chitin, and because this material usually comes...

Authors: Alvarez FJ.

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are...

Authors: Wagener J1, Malireddi RK2, Lenardon MD1, Köberle M3, Vautier S1, MacCallum DM1, Biedermann T3,...

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Research Area

Topic

Can plate dilutions schemes be transferred to WinKQCL™ Software if contained in a LIMS?

Is it possible to automate the PyroTec Pro standard dilutions?

Does the reported Log4j vulnerability threat affect our WinKQCL software (Catalog # 25-611E)?

Can you provide more information on the PyroTec Pro validation of endotoxin standards made using pipetting vs. vortexing?

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

Endotoxin recovery using limulus amebocyte lysate (LAL) assay.

Masking of endotoxin in surfactant samples: Effects on Limulus-based detection systems.

Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform

The effect of chitin size, shape, source and purification method on immune recognition.

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.