Local Transplantation of G-CSF Mobilized CD34-Positive Cells Contributes to Fracture Healing Via Vasculogenesis and Osteogenesis
Mifune Y, Matsumoto T, Kawamoto A, Kuroda R, Iwasaki H, Shoji T, Lee SY, Oyamada A, Horii M, Kurosaka M,Asahara T
Immunotherapy / Hematology
Cells used in publication:
CD34+ cell, human
Tissue Origin: blood
Failures in fracture healing are mainly caused by a lack of vascularization. We previously reported that systemic administration of adult human circulating CD34+ cells, an endothelial/hematopoietic progenitor cell-enriched cell population (1), contributes to functional fracture healing via vasculogenesis and osteogenesis in an immunodeficient rat model of non-healing fracture (2). Based on the scientific backgrounds, to widen clinical application, we performed experiments to prove a reasonable hypothesis that human peripheral blood CD34+ cells may have potential of differentiating into osteocytes in vitro, and that local transplantation of GCSF-mobilized peripheral blood CD34+ cells may further contribute to fracture healing.
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