Micro-pattern guided adhesion of osteoblasts on diamond surfaces.

Authors:
Rezek B, Michalíková L, Ukraintsev E, Kromka A, Kalbacova M.
In:
Source: Sensors
Publication Date: (2009)
Issue: 9(5): 3549-62
Research Area:
Dermatology/Tissue Engineering
Basic Research
Cells used in publication:
Fibroblast, periodontal lig.(HPdLF), human
Species: human
Tissue Origin:
Abstract
Microscopic chemical patterning of diamond surfaces by hydrogen and oxygen surface atoms is used for self-assembly of human osteoblastic cells into micro-arrays. The cell adhesion and assembly is further controlled by concentration of cells (2,500-10,000 cells/cm(2)) and fetal bovine serum (0-15%). The cells are characterized by fluorescence microscopy of actin fibers and nuclei. The serum protein adsorption is studied by atomic force microscopy (AFM). The cells are arranged selectively on O-terminated patterns into 30-200 µm wide arrays. Higher cell concentrations allow colonization of unfavorable H-terminated regions due to mutual cell communication. There is no cell selectivity without the proteins in the medium. Based on the AFM, the proteins are present on both H- and O-terminated surfaces. Pronounced differences in their thickness, surface roughness, morphology, and phase images indicate different conformation of the proteins and explain the cell selectivity.