Engagement of ICAM-3 provides a costimulatory signal for human immunodeficiency virus type 1 replication in both activated and quiescent CD4+ T lymphocytes: implications for virus pathogenesis

Barat C, Gervais P and Tremblay MJ
Source: J Virol
Publication Date: (2004)
Issue: 78(12): 6692-6697
Cells used in publication:
T cell, human peripheral blood unstim.
Species: human
Tissue Origin: blood
Human immunodeficiency virus type 1 (HIV-1) replication is regulated by several extracellular signals. We demonstrate that intercellular adhesion molecule 3 (ICAM-3) acts as a costimulating molecule to increase HIV-1 transcription and viral production, a process allowing productive infection of quiescent CD4+ T lymphocytes. The present work suggests an important role for ICAM-3 in HIV-1 replication.