Dorsal root ganglion (DRG), mouse

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A collection of neurons associated with the processing of sensory information. Found within the sensory portion of the spinal nerve, just as the nerve exits the spinal foramina.

Cell Type:
Neurons (Ganglia)
Tissue Origin:
brain
Species:
mouse
Research Area:
Neurobiology
Cell Characteristics:
Adherent

Transfection Information

Lonza Optimized Protocol
Optimization Guideline
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The table below shows data for the cell type and Nucleofector™ Platform selected. Those data are either based on Lonza Optimized Protocols or on results shared from customers who performed an optimization based on our guidelines. In case no data are shown for the selected Nucleofector™ Platform, please take a look at our optimization strategy to get further guidance on how to easily determine optimal Nucleofection conditions yourself.
Protocol Kit Program Cells Efficiency Viable Cells Substrate Format Platform
SCN Nucleofector Solution SCN program 6 3e4 30-60% 25-65% Plasmid (general) 0.4 µg 100 µl I/II/2b

Citations (17)

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.
Categories:
Transfection 
Authors:
Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmüller J, Nürnberg P, Weis J, Hübner CA, Heinemann SH, Kurth I. 
In:
Nat Commun. (2015) 8(6): 1-11 
GABA blocks pathological but not acute TRPV1 pain signals.
Categories:
Transfection 
Authors:
Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J. 
In:
Cell (2015) 160(4): 759-70 
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons
Categories:
Transfection 
Authors:
Hausott B, Schlick B, Vallant N, Dorn R, Klimaschewski L 
In:
Neuroscience (2008) 153(2): 461-73 
Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons
Categories:
Transfection 
Authors:
Hudmon A, Choi JS, Tyrrell L, Black JA, Rush AM, Waxman SG, Dib-Hajj SD 
In:
J Neurosci (2008) 28(12): 3190-201 
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics
Categories:
Transfection 
Authors:
Lewcock JW, Genoud N, Lettieri K, Pfaff SL 
In:
Neuron (2007) 56(4): 604-20 
Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes
Categories:
Transfection 
Authors:
Groth RD, Coicou LG, Mermelstein PG, Seybold VS 
In:
J Neurochem (2007) 102(4): 1162-74 
Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein
Categories:
Transfection 
Authors:
Limpert AS, Karlo JC, Landreth GE 
In:
Mol Cell Biol (2007) 27(16): 5686-98 
Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization
Categories:
Transfection 
Authors:
Harty TP, Waxman SG 
In:
Mol Pain (2007) 3(1): 12 
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
Categories:
Transfection 
Authors:
Zhou X, Babu JR, da Silva S, Shu Q, Graef IA, Oliver T, Tomoda T, Tani T, Wooten MW, Wang F 
In:
Proc Natl Acad Sci USA (2007) 104(14): 5842-7 
A stomatin-domain protein essential for touch sensation in the mouse
Categories:
Transfection 
Authors:
Wetzel C, Hu J, Riethmacher D, Benckendorff A, Harder L, Eilers A, Moshourab R, Kozlenkov A, Labuz D, Caspani O, Erdmann B, Machelska H, Heppenstall PA, Lewin GR 
In:
Nature (2007) 445(7124): 206-9 
Impaired axonal regeneration by isolectin B4-binding dorsal root ganglion neurons in vitro
Categories:
Transfection 
Authors:
Leclere PG, Norman E, Groutsi F, Coffin R, Mayer U, Pizzey J, Tonge D 
In:
J Neurosci (2007) 27(5): 1190-9 
Essential Roles for GSK-3s and GSK-3-Primed Substrates in Neurotrophin-Induced and Hippocampal Axon Growth
Categories:
Transfection 
Authors:
Kim WY, Zhou FQ, Zhou J, Yokota Y, Wang YM, Yoshimura T, Kaibuchi K, Woodgett JR, Anton ES, Snider WD 
In:
Neuron (2006) 52(6): 981-96 
Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons
Categories:
Transfection 
Authors:
Choi JS, Hudmon A, Waxman S, Dib-Hajj SD 
In:
J Neurophysiol (2006) 96(1): 97-108 
Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
Categories:
Transfection 
Authors:
Zhou FQ, Walzer M, Wu YH, Zhou J, Dedhar S, Snider WD 
In:
J Cell Sci (2006) 119(Pt 13): 2787-96 
Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons
Categories:
Transfection 
Authors:
Dib-Hajj SD, Rush AM, Cummins TR, Hisama FM, Novella S, Tyrrell L, Marshall L and Waxman SG 
In:
Brain (2005) 128(Pt 8): 1847-1854 
NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC
Categories:
Transfection 
Authors:
Zhou FQ, Zhou J, Dedhar S, Wu YH and Snider WD 
In:
Neuron (2004) 42(6): 897-912 
BPAG1n4 is essential for retrograde axonal transport in sensory neurons
Categories:
Transfection 
Authors:
Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E and Yang Y 
In:
J Cell Biol (2003) 163(2): 223-229 
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