Epithelial, mammary, human (HMEC)

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Mammary epithelial cells are isolated from glandular tissue in adult human breast tissue.

Cell Type:
Mammary Epith.
Tissue Origin:
breast
Species:
human
Research Area:
Cancer Research/Cell Biology
Cell Characteristics:
Adherent

Recommended Media

Mammary Epithelial Cell Growth Medium

Serum-free media developed specifically for growth of mammary epithelial cells.

Available in phenol red-free (basal media = CC3153) and sodium bicarbonate-free (basal media = CC-3152) versions.

Transfection Information

Lonza Optimized Protocol
Optimization Guideline
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The table below shows data for the cell type and Nucleofector™ Platform selected. Those data are either based on Lonza Optimized Protocols or on results shared from customers who performed an optimization based on our guidelines. In case no data are shown for the selected Nucleofector™ Platform, please take a look at our optimization strategy to get further guidance on how to easily determine optimal Nucleofection conditions yourself.
Protocol Kit Program Cells Efficiency Viable Cells Substrate Format Platform
P3

96-EL-110

 1e5 48-54% 58-74% Plasmid (general) 1 µg 20 µl 96-well
HMEC W-001 5e5 52-60% 78-100% Plasmid (general) 2 µg 100 µl I/II/2b
HMEC W-001 5e5 52-60% 78-100% Plasmid (general) 2 µg 100 µl I/II/2b
HMEC Y-001 5e5 67-75% 51-81% Plasmid (general) 2 µg 100 µl I/II/2b
HMEC Y-001 5e5 68-78% 60-84% Plasmid (general) 2 µg 100 µl I/II/2b
P3

EL-110

 1e5 48-54% 58-74% Plasmid (general) 1 µg 20 µl 4D X-Unit

Citations (100)

Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture.
Categories:
3D Cell Culture , Bioassay  
Authors:
Jorgens DM, Inman JL, Wojcik M, Robertson C, Palsdottir H, Tsai WT, Huang H, Bruni-Cardoso A, López CS, Bissell MJ, Xu K, Auer M 
In:
J Cell Sci (2017) 130(1): 177-189 
Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Li Y, Buckhaults P, Cui X, Tollefsbol TO 
In:
Epigenetics (2016) 8(8): 1019-37 
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Categories:
 
Authors:
Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ, Gomis RR 
In:
Nat Commun. (2016) 7: 11199 
Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression
Categories:
 
Authors:
Kmiecik AM, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P 
In:
PLoS ONE (2015) 10(5): e0124865 
Sclerotium rolfsii Lectin Induces Stronger Inhibition of Proliferation in Human Breast Cancer Cells than Normal Human Mammary Epithelial Cells by Induction of Cell Apoptosis.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Savanur MA, Eligar SM, Pujari R, Chen C, Mahajan P, Borges A, Shastry P, Ingle A, Kalraiya RD, Swamy BM, Rhodes JM, Yu LG, Inamdar SR 
In:
PLoS ONE (2014) 9(11): e110107 
PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Xing X, Zhang L, Wen X, Wang X, Cheng X, Du H, Hu Y, Li L, Dong B, Li Z, Ji J. 
In:
Anti Cancer Drugs (2014) ;25(10): 1129-40 
Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Barrio-Real L, Benedetti LG, Engel N, Tu Y, Cho S, Sukumar S, Kazanietz MG. 
In:
Breast Cancer Res (2014) 16(5): 441 
MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ 
In:
J Clin Invest (2014) 124(7): 3093-106 
In vitro antitumor activity of stellettin B, a triterpene from marine sponge Jaspis stellifera, on human glioblastoma cancer SF295 cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Tang SA, Zhou Q, Guo WZ, Qiu Y, Wang R, Jin M, Zhang W, Li K, Yamori T, Dan S, Kong D 
In:
Mar Drugs (2014) 12(7): 4200-13 
Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells
Categories:
 
Authors:
Jia Y, Domenico J, Swasey C, Wang M, Gelfand EW, Lucas JJ. 
In:
PLoS ONE (2014) 9(5): e97448 
Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Rhie SK, Hazelett DJ, Coetzee SG, Yan C, Noushmehr H, Coetzee GA 
In:
BMC Genomics (2014) 15: 331 
Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Lopatina T, Bruno S, Tetta C, Kalinina N, Porta M, Camussi G 
In:
Cell Commun Signal (2014) 12: ePub 
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe\\\'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM. 
In:
Genes Dev (2014) 28(7): 765-82 
Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Phillips S1, Prat A2, Sedic M1, Proia T3, Wronski A1, Mazumdar S4, Skibinski A1, Shirley SH5, Perou CM6, Gill G4, Gupta PB7, Kuperwasser C1. 
In:
Stem Cell Reports (2014) 2(5): 633-47 
Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.
Categories:
Primary Cells and Media 
Authors:
Gras B, Jacqueroud L, Wierinckx A, Lamblot C, Fauvet F, Lachuer J, Puisieux A, Ansieau S 
In:
PLoS ONE (2014) 9(3): e92254 
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Skibinski A, Breindel JL, Prat A, Galván P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C 
In:
Cell Rep (2014) 6(6): 1059-72 
Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties
Categories:
 
Authors:
He X, Arslan AD, Ho TT, Yuan C, Stampfer MR, Beck WT 
In:
Oncogene (2014) 3: e84 
Cell surface-associated anti-MUC1-derived signal peptide antibodies: implications for cancer diagnostics and therapy
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kovjazin R, Horn G, Smorodinsky NI, Shapira MY, Carmon L 
In:
PLoS ONE (2014) ;9(1): e85400 
Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Patnala R, Lee SH, Dahlstrom JE, Ohms S, Chen L, Dheen ST, Rangasamy D. 
In:
Breast Cancer Res (2014) 143(2): 239-53 
Down-regulation of Filamin A interacting protein 1-like Is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kwon M, Lee SJ, Reddy S, Rybak Y, Adem A, Libutti SK 
In:
PLoS ONE (2013) 8(12): e82620 
Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Hilchie AL1, Conrad DM, Coombs MR, Zemlak T, Doucette CD, Liwski RS, Hoskin DW. 
In:
Leuk Lymphoma (2013) 54(10): 10 
Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Thuringer D, Jego G, Wettstein G, Terrier O, Cronier L, Yousfi N, Hébrard S, Bouchot A, Hazoumé A, Joly AL, Gleave M, Rosa-Calatrava M, Solary E, Garrido C. 
In:
FASEB J (2013) 27(10): 4169-83 
Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Jiang G1, Xiao X, Zeng Y, Nagabhushanam K, Majeed M, Xiao D. 
In:
BMC Complemen Altern Med (2013) 13: 203 
Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Li Y1, Chen H, Hardy TM, Tollefsbol TO. 
In:
PLoS ONE (2013) 8(1): e54369 
Characterization of spontaneous and TGF-ß-induced cell motility of primary human normal and neoplastic mammary cells in vitro using novel real-time technology.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Mandel K1, Seidl D, Rades D, Lehnert H, Gieseler F, Hass R, Ungefroren H. 
In:
PLoS ONE (2013) 8(2): e56591 
Potassium channel KCNA1 modulates oncogene-induced senescence and transformation
Categories:
 
Authors:
Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D 
In:
Cancer Res (2013) 73(16): 5253-65 
Comprehensive functional annotation of seventy-one breast cancer risk Loci.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Rhie SK1, Coetzee SG, Noushmehr H, Yan C, Kim JM, Haiman CA, Coetzee GA. 
In:
PLoS ONE (2013) 8(5): e63925 
The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K 
In:
J Biol Chem (2013) 288(19): 13269-77 
HDAC11 is a novel drug target in carcinomas
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Deubzer HE1, Schier MC, Oehme I, Lodrini M, Haendler B, Sommer A, Witt O. 
In:
Int J Cancer (2013) 132(9): 2200-8 
GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation.
Categories:
Primary Cells and Media 
Authors:
Goel HL1, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. 
In:
EMBO Mol Med (2013) 5(4): 488-508 
Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Rajput S1, Kumar BN, Sarkar S, Das S, Azab B, Santhekadur PK, Das SK, Emdad L, Sarkar D, Fisher PB, Mandal M. 
In:
PLoS ONE (2013) 8(4): e61342 
Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Vlaicu P1, Mertins P, Mayr T, Widschwendter P, Ataseven B, Högel B, Eiermann W, Knyazev P, Ullrich A. 
In:
BMC Cancer (2013) 13: 197 
Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS 
In:
Cancer Res (2013) 73(7): 2070-81 
Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.
Categories:
 
Authors:
Chou TF1, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ. 
In:
Other (2013) 8(2): 297-312 
Epigenetic reactivation of estrogen receptor-a (ERa) by genistein enhances hormonal therapy sensitivity in ERa-negative breast cancer.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Li Y1, Meeran SM, Patel SN, Chen H, Hardy TM, Tollefsbol TO. 
In:
Mol Cancer (2013) 4: 12:9 
Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells
Categories:
 
Authors:
Wu AM, Dalvi P, Lu X, Yang M, Riddick DS, Matthews J, Clevenger CV, Ross DD, Harper PA, Ito S 
In:
Mol Pharmacol (2013) 83(2): 377-88 
TFPIa and TFPIß are expressed at the surface of breast cancer cells and inhibit TF-FVIIa activity.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Stavik B, Tinholt M, Sletten M, Skretting G, Sandset PM, Iversen N. 
In:
J Hematol Oncol (2013) 6: 5 
AMP-Activated Protein Kinase a 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Fox MM1, Phoenix KN, Kopsiaftis SG, Claffey KP. 
In:
Genes Cancer (2013) 4(1-2): 3-14 
STOP gene Phactr4 is a tumor suppressor
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Solimini NL1, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ. 
In:
Proc Natl Acad Sci USA (2013) 110(5): E407-14 
Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples
Categories:
 
Authors:
Boersema PJ, Geiger T, Wisniewski JR, Mann M 
In:
Mol Cell Proteomics (2013) 12(1): 158-71 
SOX4 mediates TGF-ß-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Vervoort SJ, Lourenço AR, van Boxtel R, Coffer PJ. 
In:
PLoS ONE (2013) 8(1): e53238 
Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Chen L1, Dahlstrom JE, Chandra A, Board P, Rangasamy D. 
In:
Breast Cancer Res (2012) 136(1): 129-42 
Wnt antagonist SFRP1 functions as a secreted mediator of senescence
Categories:
 
Authors:
Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y 
In:
Mol Cell Biol (2012) 32(21): 4388-99 
1\\\'-Acetoxychavicol acetate inhibits growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
In LL1, Arshad NM, Ibrahim H, Azmi MN, Awang K, Nagoor NH. 
In:
BMC Complemen Altern Med (2012) 12: 179 
7a-Hydroxy-ß-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular Bax/Bcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK1/2 Activation.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Tasyriq M1, Najmuldeen IA, In LL, Mohamad K, Awang K, Hasima N. 
In:
Evid. Based Complemtnt. Alternate. Med (2012) 2012: 765316 
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice
Categories:
Primary Cells and Media 
Authors:
Morel AP1, Hinkal GW, Thomas C, Fauvet F, Courtois-Cox S, Wierinckx A, Devouassoux-Shisheboran M, Treilleux I, Tissier A, Gras B, Pourchet J, Puisieux I, Browne GJ, Spicer DB, Lachuer J, Ansieau S, Puisieux A. 
In:
PLoS Genet (2012) 8(5): e1002723 
Dichotomy effects of Akt signaling in breast cancer
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Peng Z1, Weber JC, Han Z, Shen R, Zhou W, Scott JR, Chan MW, Lin HJ. 
In:
Mol Cancer (2012) 11: 61 
Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Gong Y1, Li Y, Abdolmaleky HM, Li L, Zhou JR. 
In:
PLoS ONE (2012) 7(4): e33656 
Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Hansen BF1, Glendorf T, Hegelund AC, Lundby A, Lützen A, Slaaby R, Stidsen CE. 
In:
PLoS ONE (2012) 7(5): e34274 
Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ichikawa T1, Sato F, Terasawa K, Tsuchiya S, Toi M, Tsujimoto G, Shimizu K. 
In:
PLoS ONE (2012) 7(2): e31422 
NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Jiang J1, Thyagarajan-Sahu A, Krchnák V, Jedinak A, Sandusky GE, Sliva D. 
In:
PLoS ONE (2012) 7(3): e34283 
Epigenetic repression of RARRES1 is mediated by methylation of a proximal promoter and a loss of CTCF binding.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Peng Z1, Shen R, Li YW, Teng KY, Shapiro CL, Lin HJ. 
In:
PLoS ONE (2012) 7(5): e36891 
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Cerna D1, Li H, Flaherty S, Takebe N, Coleman CN, Yoo SS 
In:
J Biol Chem (2012) 287(26): 22408-17 
Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Issaenko OA1, Amerik AY. 
In:
Cell Cycle. (2012) 11(9): 1804-17 
Proteomic portrait of human breast cancer progression identifies novel prognostic markers
Categories:
Primary Cells and Media 
Authors:
Geiger T, Madden SF, Gallagher WM, Cox J, Mann M 
In:
Cancer Res (2012) 72(9): 2428-39 
Development of a novel class of glucose transporter inhibitors.
Categories:
 
Authors:
Wang D1, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. 
In:
J Med Chem (2012) 3827-36: 3827-36 
Metformin reduces endogenous reactive oxygen species and associated DNA damage
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Algire C, Moiseeva O, Deschênes-Simard X, Amrein L, Petruccelli L, Birman E, Viollet B, Ferbeyre G, Pollak MN 
In:
Other (2012) 5(4): 536-43 
Epithelial cell guidance by self-generated EGF gradients
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Scherber C1, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D. 
In:
Integr Biol (Camb). (2012) 4(3):: 259-69 
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.
Categories:
 
Authors:
Hon GC1, Hawkins RD, Caballero OL, Lo C, Lister R, Pelizzola M, Valsesia A, Ye Z, Kuan S, Edsall LE, Camargo AA, Stevenson BJ, Ecker JR, Bafna V, Strausberg RL, Simpson AJ, Ren B. 
In:
Genome Res (2012) 22(2): 246-58 
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
D\\\\\\\\\\\\\\\'Amato NC1, Ostrander JH, Bowie ML, Sistrunk C, Borowsky A, Cardiff RD, Bell K, Young LJ, Simin K, Bachelder RE, Delrow J, Dawson A, Yee LD, Mrózek K, Clay TM, Osada T, Seewaldt VL. 
In:
PLoS ONE (2012) 7(9): e45684 
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor a in breast cancer.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Elangovan S1, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M. 
In:
Cancer Res (2011) 71(21): 6654-64 
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Pandey PR1, Okuda H, Watabe M, Pai SK, Liu W, Kobayashi A, Xing F, Fukuda K, Hirota S, Sugai T, Wakabayashi G, Koeda K, Kashiwaba M, Suzuki K, Chiba T, Endo M, Fujioka T, Tanji S, Mo YY, Cao D, Wilber AC, Watabe K. 
In:
Breast Cancer Res (2011) 130(2): 387-98 
Identification and characterization of a novel integrin-linked kinase inhibitor.
Categories:
Primary Cells and Media 
Authors:
Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. 
In:
J Med Chem (2011) 54(18): 6364-74 
Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis
Categories:
Primary Cells and Media 
Authors:
Sin S, Bonin F, Petit V, Meseure D, Lallemand F, Bièche I, Bellahcène A, Castronovo V, de Wever O, Gespach C, Lidereau R, Driouch K 
In:
J Natl Cancer Inst (2011) 103(17): 1323-37 
In vitro generation of human cells with cancer stem cell properties.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Scaffidi P1, Misteli T. 
In:
Nat Cell Biol (2011) 13(9):: 1051-61 
Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/ß-catenin-mediated transcription in human breast tumor cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Tinsley HN1, Gary BD, Keeton AB, Lu W, Li Y, Piazza GA. 
In:
Cancer Prev Res (Phila). (2011) 4(8): 1275-84 
Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ru P1, Steele R, Hsueh EC, Ray RB. 
In:
Genes Cancer (2011) 2(7): 720-7 
Mapping and analysis of chromatin state dynamics in nine human cell types.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE 
In:
Nature (2011) 473(7345): 43-9 
K(Ca)3.1 channels facilitate K+ secretion or Na+ absorption depending on apical or basolateral P2Y receptor stimulation
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Palmer ML, Peitzman ER, Maniak PJ, Sieck GC, Prakash YS, O\\\'Grady SM 
In:
J Physiol (2011) 589(Pt 14): 3483-94 
An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Donatello S1, Hudson L, Cottell DC, Blanco A, Aurrekoetxea I, Shelly MJ, Dervan PA, Kell MR, Stokes M, Hill AD, Hopkins AM. 
In:
J Exp Clin Cancer Res (2011) 30: 45 
2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
DeAngelis JT1, Li Y, Mitchell N, Wilson L, Kim H, Tollefsbol TO. 
In:
J Proteome Res (2011) 10(2): 447-58 
Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering.
Categories:
Primary Cells and Media 
Authors:
El-Said WA1, Kim TH, Kim H, Choi JW. 
In:
PLoS ONE (2011) 6(2): e15836 
Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Zhang H1, Gogada R, Yadav N, Lella RK, Badeaux M, Ayres M, Gandhi V, Tang DG, Chandra D. 
In:
PLoS ONE (2011) 6(1): e16379 
Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Whipple RA1, Matrone MA, Cho EH, Balzer EM, Vitolo MI, Yoon JR, Ioffe OB, Tuttle KC, Yang J, Martin SS. 
In:
Cancer Res (2010) 70(20): 8127-37 
Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yuan K1, Frolova N, Xie Y, Wang D, Cook L, Kwon YJ, Steg AD, Serra R, Frost AR. 
In:
J. Histochem Cytochem (2010) 58(10): 857-70 
Proteomic changes resulting from gene copy number variations in cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Geiger T1, Cox J, Mann M. 
In:
PLoS ONE (2010) 6(9): e1001090 
Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Wang X1, He S, Sun JM, Delcuve GP, Davie JR. 
In:
Mol Biol Cell (2010) 21(17): 2987-95 
A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Guerrant W1, Mwakwari SC, Chen PC, Khan SI, Tekwani BL, Oyelere AK. 
In:
ChemMedChem. (2010) 5(8): 1232-5 
Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media, Transfection 
Authors:
Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, Fujioka T, Nakamura Y, Katagiri T. 
In:
Cancer Res (2010) 70(14): 5829-39 
Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Baldwin A1, Grueneberg DA, Hellner K, Sawyer J, Grace M, Li W, Harlow E, Munger K. 
In:
Proc Natl Acad Sci USA (2010) 107(28): 12463-8 
Optical redox ratio differentiates breast cancer cell lines based on estrogen receptor status
Categories:
 
Authors:
Ostrander JH, McMahon CM, Lem S, Millon SR, Brown JQ, Seewaldt VL, Ramanujam N 
In:
Cell Res (2010) 70(11): 4759-66 
Multimodal regulation of E2F1 gene expression by progestins
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Wade HE1, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP. 
In:
Mol Cell Biol (2010) 30(8): 1866-77 
Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ray RB1, Raychoudhuri A, Steele R, Nerurkar P. 
In:
Cancer Res (2010) 70(5): 1925-31 
Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Fogal V1, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. 
In:
Mol Cell Biol (2010) 30(6): 1303-18 
Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ruike Y1, Imanaka Y, Sato F, Shimizu K, Tsujimoto G. 
In:
BMC Genomics (2010) 11: 137 
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Lin L1, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J 
In:
Neoplasia (2010) 12(1): 39-50 
Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Millon SR1, Ostrander JH, Yazdanfar S, Brown JQ, Bender JE, Rajeha A, Ramanujam N. 
In:
J Bio Med Opt (2010) 15(1): 018002 
Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Zhang J1, Li Y, Liu Q, Lu W, Bu G. 
In:
Oncogene (2010) 29(4): 539-49 
The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Liu Y1, Morgan JB, Coothankandaswamy V, Liu R, Jekabsons MB, Mahdi F, Nagle DG, Zhou YD. 
In:
J Nat Prod (2009) 72(12): 2104-9 
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Tinsley HN1, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA. 
In:
Mol Cancer Ther (2009) 8(12): 3331-40 
Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Wong C1, Chen S. 
In:
Cancer Res (2009) 69(22): 8670-7 
Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Liu L1, Derguini F, Gudas LJ. 
In:
J Cell Physiol (2009) 220(3): 771-9 
Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Su S1, Li Y, Luo Y, Sheng Y, Su Y, Padia RN, Pan ZK, Dong Z, Huang S. 
In:
Oncogene (2009) 28(34): 3047-57 
Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Thibodeaux CA1, Liu X, Disbrow GL, Zhang Y, Rone JD, Haddad BR, Schlegel R. 
In:
Breast Cancer Res (2009) 116(2): 281-94 
Phototoxic aptamers selectively enter and kill epithelial cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ferreira CS1, Cheung MC, Missailidis S, Bisland S, Gariépy J. 
In:
Nucleic Acids Res (2009) 37(3): 866-76 
Tumor and vascular targeting of a novel oncolytic measles virus retargeted against the urokinase receptor.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Jing Y1, Tong C, Zhang J, Nakamura T, Iankov I, Russell SJ, Merchan JR. 
In:
Cancer Res (2009) 69(4): 1459-68 
Targeting aspartate aminotransferase in breast cancer.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Thornburg JM1, Nelson KK, Clem BF, Lane AN, Arumugam S, Simmons A, Eaton JW, Telang S, Chesney J. 
In:
Breast Cancer Res (2008) 10(5): R84 
Generation of breast cancer stem cells through epithelial-mesenchymal transition.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Morel AP1, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. 
In:
PLoS ONE (2008) 3(8): e2888 
Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Lee CW1, Raskett CM, Prudovsky I, Altieri DC. 
In:
Cancer Res (2008) 68(13): 5273-81 
The BRG1- and hBRM-Associated Factor BAF57 Induces Apoptosis by Stimulating Expression of the Cylindromatosis Tumor Suppressor Gene
Categories:
Transfection 
Authors:
Wang L, Baiocchi RA, Pal S, Mosialos G, Caligiuri M and Sif S 
In:
Mol Cell Biol (2005) 25(18): 7953-7965 
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