Adipocyte (pre), human diabetes Tp.1

Preadipocytes are precursor cells that develop into adipocytes when fully differentiated. Adipocytes perform essential functions of energy metabolism and are characterized by the accumulation of intracellular triglycerides.

Preadipocyte Cells are isolated from subcutaneous or visceral fat. Subcutaneous fat is often found attached to skin in the lower abdomen area. Visceral preadipocytes are isolated from adipose tissue associated with internal organs, such as the bladder or kidney.

Relative to subcutaneous fat, visceral fat deposits are mobilized at a higher rate to produce serum fatty acids which contribute to insulin resistance, Diabetes Type 2, and other related cardiovascular disorders.

Diabetes mellitus type 1 (Type 1 diabetes, IDDM, or, formerly, juvenile diabetes) is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas. It can be treated with Insulin injections.

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Recommended Media

Our Preadipocyte Growth Media-2 (PGM™-2) is optimized for preadipocyte proliferation, and differentiation in only 10 days of culture time. The media contains no glitazones that can interfere with PPAR-gamma activity measurements. The media used with our cells compose a robust system that requires no media changes during the culture time to differentiate.

Transfection Information

In case no data are shown for the selected cell type, please take a look at our optimization strategy or contact our Scientific Support Teams to get further guidance on how to easily determine optimal Nucleofection conditions yourself.