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4536 results sorted by

The High-Affinity Immunoglobulin-E Receptor (FcepsilonRI) is Endocytosed by an AP-2/Clathrin-Independent, Dynamin-Dependent Mechanism

Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcepsilonRI), expressed on mast cells and basophils, initiates the immediate hypersensitivity reaction. Aggregated FcepsilonRI has been reported to rapidly migrate to lipid rafts in...
Authors: Fattakhova G, Masilamani M, Borrego F, Gilfillan AM, Metcalfe DD, Coligan JE

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

17-Allylamino-demethoxy geldanamycin (17-AAG) inhibits the chaperone association of heat shock protein 90 (hsp90) with the heat shock factor-1 (HSF-1), which induces the mRNA and protein levels of hsp70. Increased hsp70 levels inhibit death receptor...
Authors: Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, Kumaraswamy S, Balasis M, Greedy B,...

Nucleofection, an efficient nonviral method to transfer genes into human hematopoietic stem and progenitor cells

The targeted manipulation of the genetic program of single cells as well as of complete organisms has strongly enhanced our understanding of cellular and developmental processes and should also help to increase our knowledge of primary human stem...
Authors: von Levetzow G, Spanholtz J, Beckmann J, Fischer J, Kogler G, Wernet P, Punzel M, Giebel B

Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase (hTERT) promoter activity by the bioactive sphingolipid ceramide

In this study, roles of Sp1/Sp3 transcription factors in the regulation of the activity of human telomerase reverse transcriptase (hTERT) promoter in response to ceramide were examined in the A549 human lung adenocarcinoma cells. The activity of the...
Authors: Wooten LG and Ogretmen B

Biphasic regulation by bile acids of dermal fibroblast proliferation through regulation of cAMP production and COX-2 expression level

We have previously reported that the bile acids chenodeoxycholate (CDCA), and ursodeoxycholate (UDCA), decreased PGE1-induced cAMP production not only in hepatocytes but also in non-hepatic cells including dermal fibroblasts. In the present study we...
Authors: Meng J, Ceryak S, Arastu Z, Jones L, Epstein L, Bouscarel B

TGF-beta1 in SP-A preparations influences immune suppressive properties of SP-A on human CD4+ T lymphocytes

Surfactant protein A (SP-A) and transforming growth factor-beta(1) (TGF-beta1) have been shown to modulate the functions of different immune cells and specifically to inhibit T lymphocyte proliferation. The aim of the present study was to elucidate...
Authors: Kunzmann S, Wright JR, Steinhilber W, Kramer BW, Blaser K, Speer CP, Schmidt-Weber C

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Disease-producing mutations of ion channels are usually characterized as producing hyperexcitability or hypoexcitability. We show here that a single mutation can produce hyperexcitability in one neuronal cell type and hypoexcitability in another...
Authors: Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG

Localization of cardiac L-type Ca2+ channels to a caveolar macromolecular signaling complex is required for 2-adrenergic regulation

L-type Ca(2+) channels play a critical role in regulating Ca(2+)-dependent signaling in cardiac myocytes, including excitation-contraction coupling; however, the subcellular localization of cardiac L-type Ca(2+) channels and their regulation are...
Authors: Balijepalli RC, Foell JD, Hall DD, Hell JW, Kamp TJ

Dysregulated T cell expression of TIM3 in multiple sclerosis

T cell immunoglobulin- and mucin domain-containing molecule (TIM)3 is a T helper cell (Th)1-associated cell surface molecule that regulates Th1 responses and promotes tolerance in mice, but its expression and function in human T cells is unknown. We...
Authors: Koguchi K, Anderson DE, Yang L, O'connor KC, Kuchroo VK, Hafler DA

Requirement of clathrin heavy chain for p53-mediated transcription

The p53 protein is a transcription factor that activates various genes responsible for growth arrest and/or apoptosis in response to DNA damage. Here, we report that clathrin heavy chain (CHC) binds to p53 and contributes to p53-mediated...
Authors: Enari M, Ohmori K, Kitabayashi I, Taya Y