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Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent-catenin degradation

Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing beta-catenin in many biological systems. We have uncovered a new...
Authors: Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ and Yang Y

Rapid and highly efficient gene transfer into natural killer cells by nucleofection

Natural killer (NK) cells are important mediators of virus- and tumor-specific immune responses. The transfection of genes into NK cells has been proven difficult and so far requires infection with virus-based vectors. Here, the application of a...
Authors: Trompeter HI, Weinhold S, Thiel C, Wernet P and Uhrberg M

Production of PtdIns(5)P by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

MTM1, the gene encoding myotubularin (MTM1), is mutated in the X-linked myotubular myopathy (XLMTM), a severe genetic muscular disorder. MTM1 is a phosphoinositide phosphatase hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P) in yeast and in...
Authors: Tronchere H, Laporte J, Pendaries C, Chaussade C, Liaubet L, Pirola L, Mandel JL and Payrastre B

Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk

The multilineage differentiation potential of adult tissue-derived mesenchymal progenitor cells (MPCs), such as those from bone marrow and trabecular bone, makes them a useful model to investigate mechanisms regulating tissue development and...
Authors: Tuli R, Tuli S, Nandi S, Huang X, Manner PA, Hozack WJ, Danielson KG, Hall DJ and Tuan RS

Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification

Anergy is a state of immunologic tolerance in which T cells are viable but incapable of responding to antigenic stimulation. Recent data indicate that anergic cells have a distinct gene expression program that determines their unique function. In...
Authors: Tzachanis D, Appleman LJ, van Puijenbroek AAFL, Berezovskaya A, Nadler LM and Boussiotis VA

Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase A inhibits T cell receptor signaling

Raft-associated Csk controls signaling through the T cell receptor (TCR) and was mainly anchored to Cbp/PAG (phosphoprotein associated with glycosphingolipid-enriched membrane domains). Treatment of cells with the cAMP-elevating agent prostaglandin...
Authors: Vang T, Abrahamsen H, Myklebust S, Horejesi V and Taskén K

A central role for the Jun-N-terminal kinase pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven Smad3/4 specific gene expression

We have focused our attention on the molecular events underlying the antagonistic activities of pro-inflammatory cytokines against transforming growth factor-beta (TGF-beta)/SMAD signaling. Using jnk1/2-knockout (jnk(-/-)) and I kappa B...
Authors: Verrecchia F, Tacheau C, Wagner EF and Mauviel A

Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the expression of the human COL1A2 gene by TNF-alpha

We used a gene knockout approach to elucidate the specific roles played by the Jun-N-terminal kinase (JNK) and NF-kappaB pathways downstream of TNF-alpha in the context of alpha(2) type I collagen gene (COL1A2) expression. In JNK1-/--JNK2-/- (JNK-/-)...
Authors: Verrecchia F, Wagner EF and Mauviel A

Coordinate notch 3-hairy related transscription factor pathway regulation in response to arterial injury: mediator role of PDGF and ERK

The Notch family of receptors and downstream effectors plays a critical role in cell fate determination during vascular ontogeny. Moreover, the human cerebral autosomal dominant artriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
Authors: Wang W, Campos AH, Prince CZ, Mou Y and Pollmann MJ

Interactions of human myosin Va isoforms, endogenously expressed in human melanocytes, are tightly regulated by the tail domain

Primary human epidermal melanocytes express six endogenous isoforms of the human actin-associated myosin Va motor protein, involved in organelle transport. As isoforms containing exon F are most abundant in melanocytes, we hypothesized that these...
Authors: Westbroek W, Lambert J, Bahadoran P, Busca R, Herteleer MC, Smit N, Mommaas M, Ballotti R and...
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