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CD154 transcriptional regulation in primary human CD4 T cells

CD154 (CD40-ligand) has a wide variety of pleiotropic effects throughout the immune system and is critical to both cellular and humoral immunity. Cell surface and soluble CD154 are primarily expressed by activated CD4 T cells. Expression of CD154 is...
Authors: Cron RQ

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

Fat cadherins form a distinct subfamily of the cadherin gene superfamily, and are featured by their unusually large extracellular domain. In this work, we investigated the function of a mammalian Fat cadherin. Fat1 was localized at filopodial tips,...
Authors: Tanoue T and Takeichi M

Rapid and efficient electroporation-based gene transfer into primary dissociated neurons

Non-viral gene transfer into neurons has proved to be a formidable task. Here, we describe an electroporation-based method that allows efficient and reliable DNA transfer into dissociated neural cells before they are plated and cultured. In...
Authors: Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M and Dityatev A
SST Peer Reviewed

NF-kappaB regulates the expression of human complement receptor 2 gene

CR2 is a key regulator of the B cell response to Ag. Here we show that NF-kappaB enhances the expression of the human CR2 gene. Promoter truncation, deletion, and mutagenesis studies indicated a functional role for a consensus NF-kappaB promoter...
Authors: Tolnay M, Vereshchagina LA and Tsokos GC

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A-induced cell death

Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been implicated in ER stress-induced apoptosis and amyloid-beta...
Authors: Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y,...

Downregulation of TGFbeta isoforms and their receptors contributes to keratinocyte hyperproliferation in psoriasis vulgaris

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory disorder characterized by epidermal hyperproliferation. Transforming growth factor beta (TGFbetas) have a major antiproliferative action in epidermis. OBJECTIVE: We evaluated the distribution...
Authors: Doi H, Shibata MA, Kiyokane K and Otsuki Y

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent-catenin degradation

Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing beta-catenin in many biological systems. We have uncovered a new...
Authors: Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ and Yang Y

Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors

Daily alphavbeta5 integrin-dependent phagocytosis of spent photoreceptor outer segment fragments by the retinal pigment epithelium (RPE) is critical for retinal function. This study identifies a key role for focal adhesion kinase (FAK) in RPE...
Authors: Finnemann SC

Rapid and highly efficient gene transfer into natural killer cells by nucleofection

Natural killer (NK) cells are important mediators of virus- and tumor-specific immune responses. The transfection of genes into NK cells has been proven difficult and so far requires infection with virus-based vectors. Here, the application of a...
Authors: Trompeter HI, Weinhold S, Thiel C, Wernet P and Uhrberg M

Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells

von-Willebrand factor (vWF) and tissue-type plasminogen activator (tPA) are products of endothelial cells acutely released into the vasculature following cell activation. Both factors are secreted after intraendothelial Ca(2+) mobilization, but...
Authors: Knop M, Aareskjold E, Bode G and Gerke V
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