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Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase C in Dopaminergic Neuronal Cells

Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA. Oxidative stress is a key apoptotic stimulus in neuronal cell death and has been implicated in the pathogenesis of many...

Authors: Kaul S, Anantharam V, Yang Y, Choi C, Kanthasamy A and Kanthasamy A

Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes

c-fos, which encodes a transcription factor of the AP-1 family, is a prototypical immediate-early gene induced by a number of proinflammatory cytokines including interleukin-1 (IL-1), the latter being an important regulator of skin homeostasis. Using...

Authors: Schiller M, Bohm M, Dennler S, Ehrchen JM, Mauviel A

Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling

B cell responses are initiated by the clustering of the B cell receptor (BCR) by the binding of multivalent antigens. Clustering leads to phosphorylation of tyrosines in the cytoplasmic domains of the BCR by the inner plasma membrane...

Authors: Sohn HW, Tolar P, Jin T, Pierce SK

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

Mutations in Wnt pathway genes are rare in human breast cancer, yet activation of the pathway is evident from the misolocalization of beta-catenin. We searched for relationships in the expression of Wnt pathway genes and found that both secreted...

Authors: Shulewitz M, Soloviev I, Wu T, Koeppen H, Polakis P, Sakanaka C

The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells

PURPOSE: The purpose of this study was to characterize interactions between the farnesyltransferase inhibitor L744832 and the checkpoint abrogator UCN-01 in drug-sensitive and drug-resistant human myeloma cell lines and primary CD138+ multiple...

Authors: Pei XY, Dai Y, Rahmani M, Li W, Dent P and Grant S

Apoptotic cells promote macrophage survival by releasing the anti-apoptotic mediator sphingosine-1-phosphate

Programmed cell death is vital for a number of pathophysiologic settings. Apoptotic cells are rapidly engulfed by phagocytes (ie, macrophages), which in turn acquire an anti-inflammatory phenotype known as alternative activation or the M2-type. Here...

Authors: Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B

Effects of dynactin disruption and Dynein depletion on axonal microtubules

We investigated potential roles of cytoplasmic dynein in organizing axonal microtubules either by depleting dynein heavy chain from cultured neurons or by experimentally disrupting dynactin. The former was accomplished by siRNA while the latter was...

Authors: Ahmad FJ, He Y, Myers KA, Hasaka TP, Francis F, Black MM, Baas PW

In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins

The primary granule proteins (PGP) of myeloid cells are a source of multiple antigens with immunotherapeutic potential for myeloid leukemias. Therefore, we developed a method to induce T-cell responses to PGP protein sequences. We found that...

Authors: Fujiwara H, Melenhorst JJ, El Ouriaghli F, Kajigaya S, Grube M, Sconocchia G, Rezvani K, Price DA,...

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

We have shown that the proteasome inhibitor bortezomib (formerly known as PS-341) triggers significant antitumor activity in multiple myeloma (MM) in both preclinical models and patients with relapsed refractory disease. Recent studies have shown...

Authors: Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, Schreiber SL and Anderson KC

EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ERM proteins

EWI-2 and EWI-F, two members of a novel subfamily of Ig proteins, are direct partners of tetraspanins CD9 (Tspan29) and CD81 (Tspan28). These EWI proteins contain a stretch of basic charged amino acids in their cytoplasmic domains that may act as...

Authors: Sala-Valdes M, Ursa A, Charrin S, Rubinstein E, Hemler ME, Sanchez-Madrid F, Yanez-Mo M

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