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Carboxyl termini of P/Q-type Ca2+ channel 1A subunits translocate to nuclei and promote polyglutmine-mediated toxicity

P/Q-type voltage-gated calcium channels are regulated, in part, through the cytoplasmic carboxyl terminus (C terminus) of their alpha1A subunit. Genetic absence or alteration of the C terminus leads to abnormal channel function and neurological...
Authors: Kordasiewicz HB, Thompson RM, Clark HB, Gomez CM

Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation

We have shown previously that caspases were specifically involved in the differentiation of peripheral blood monocytes into macrophages while not required for monocyte differentiation into dendritic cells. To identify caspase targets in monocytes...
Authors: Cathelin S, Rebe C, Haddaoui L, Simioni N, Verdier F, Fontenay M, Launay S, Mayeux P, Solary E

MAG inhibits microtubule assembly by a Rho-kinase dependent mechanism

Myelin-associated glycoprotein (MAG) and Nogo are potent inhibitors of neurite outgrowth from a variety of neurons, and they have been identified as possible components of the central nervous system (CNS) myelin that prevents axonal regeneration in...
Authors: Mimura F, Yamagishi S, Arimura N, Fujitani M, Kubo T, Kaibuchi K, Yamashita T

FAK-dependent regulation of myofibroblast differentiation

Fibroblasts and myofibroblasts both participate in wound healing.Transforming growth factor beta (TGF) induces fibroblasts to( )differentiate into myofibroblasts, whereas fibroblast growth( )factor and heparin (FGF/h) induce myofibroblasts to...
Authors: Greenberg RS, Bernstein AM, Benezra M, Gelman IH, Taliana L, Masur SK

The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression

The IR2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich tract and yet retaining binding domains for DNA and TFIIB and nuclear localization...
Authors: Kim SK, Ahn BC, Albrecht RA, O'callaghan DJ

Transcriptional Regulation of Lung Cytidylyltransferase in Developing Transgenic Mice

Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant...
Authors: McCoy DM, Fisher K, Robichaud J, Ryan AJ, Mallampalli RK

SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization

The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared with normal tissue based on whole-genome expression profiling of 166 clinical bladder tumor samples and 27 normal urothelium samples. Using a SOX4-specific...
Authors: Aaboe M, Birkenkamp-Demtroder K, Wiuf C, Sorensen FB, Thykjaer T, Sauter G, Jensen KM, Dyrskjot L,...

Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton

The expression of podoplanin, a small mucin-like protein, is upregulated in the invasive front of a number of human carcinomas. We have investigated podoplanin function in cultured human breast cancer cells, in a mouse model of pancreatic beta cell...
Authors: Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, Christofori G

Cytoplasmic IRE1alpha -mediated XBP1 mRNA splicing in the absence of nuclear processing and ER stress

Accumulation of unfolded proteins in the endoplasmic reticulum activates an intracellular signal transduction program termed the Unfolded Protein Response (UPR). In mammalian cells, the UPR is signaled in part through dimerization of ER...
Authors: Back SH, Lee K, Vink E, Kaufman RJ

The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism

Mechanisms of lethality of the three-substituted indolinone and putatively selective cyclin-dependent kinase (CDK)2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) were examined in human leukemia cells....
Authors: Gao N, Kramer L, Rahmani M, Dent P, Grant S
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