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4536 results sorted by

Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor-immunity

Lymphoma cells are malignant cells of the T- or B-cell lineage which often express many surface markers inappropriately, yet are not recognized as abnormal by the immune system. We modeled this situation by inoculating ovalbumin-expressing E.G7-OVA...
Authors: Maksimow M, Miiluniemi M, Marttila-Ichihara F, Jalkanen S, Hanninen A

N-Terminal Proteolysis of the Endothelin B Receptor Abolishes Its Ability to Induce EGF Receptor Transactivation and Contractile Protein Expression in Vascular Smooth Muscle Cells

OBJECTIVE: The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent manner, but the physiological role of this N-terminal proteolysis is not known. In this study, we aimed to determine...
Authors: Grantcharova E, Reusch HP, Grossmann S, Eichhorst J, Krell HW, Beyermann M, Rosenthal W, Oksche A

ATP binding to a unique site in the type-1 S2- Inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A

The subtype and splice variant specific modulation of Inositol 1,4,5-trisphosphate receptors (InsP3R) by interaction with cellular factors plays a fundamental role in defining the characteristics of Ca2+ release in individual cell types. In this...
Authors: Wagner LE, Betzenhauser MJ, Yule DI

Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons

Sodium channel Nav1.8 produces a slowly-inactivating, tetrodotoxin-resistant current which is characterized by recovery from inactivation with fast and slow components, and contributes a substantial fraction of the current underlying the depolarizing...
Authors: Choi JS, Hudmon A, Waxman S, Dib-Hajj SD

Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon-

Interleukin (IL) -12 is a major inducer of interferon gamma (IFN-gamma) and the principal mediator of T helper (Th)1 differentiation. To identify IL-12-regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed...
Authors: Pesu M, Muul L, Kanno Y, O'shea JJ

The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse

The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes. Upon activation, these vesicles are transported to the cytotoxic...
Authors: Lettau M, Qian J, Linkermann A, Latreille M, Larose L, Kabelitz D, Janssen O

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop

The 5-HT(3) receptor is a member of the Cys-loop family of ligand-gated ion channels. The extracellular domains of these proteins contain six amino acid loops (A - F) which converge to form the ligand binding site. In this study we have mutated 21...
Authors: Thompson AJ, Padgett CL, Lummis SC

Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma

Emerging evidence suggests that both human stem cells and mature stromal cells can play an important role in the development and growth of human malignancies. In contrast to these tumor-promoting properties, we observed that in an in vivo model of...
Authors: Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hall G,...

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using...
Authors: Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS

Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma

A broad range of malignant diseases, such as mantle cell lymphoma (MCL), is associated with complex genomic alterations, demanding multimodal functional testing of candidate genes. To assess such candidate disease genes, we have developed a...
Authors: Pscherer A, Schliwka J, Wildenberger K, Mincheva A, Schwaenen C, Dohner H, Stilgenbauer S, Lichter...