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4633 results sorted by

JNK-dependent release of mitochondrial protein, SMAC during apoptosis in multiple myeloma (MM) cells

Smac, second mitochondria-derived activator of caspases, promotes apoptosis via activation of caspases. Previous studies have shown that c-Jun NH(2)-terminal kinase (JNK) is involved in regulating another mitochondrial protein, cytochrome c during...
Authors: Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Midsiades N, Munshi N, Kharbanda S and Anderson...

Pericyte-specific expression of RGs5: implications for PDGF and EDG receptor signaling during vascular maturation

RGS proteins finely tune heterotrimeric G-protein signaling. Implying the need for such fine-tuning in the developing vascular system, in situ hybridization revealed a striking and extensive expression pattern of Rgs5 in the arterial walls of...
Authors: Cho H, Kozasa T, Bondjers C, Betsholtz C and Kehrl JH

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Apoptosis is a form of programmed cell death that is controlled by aspartate-specific cysteine proteases called caspases. In the immune system, apoptosis counters the proliferation of lymphocytes to achieve a homeostatic balance, which allows potent...
Authors: Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG,...
SST Peer Reviewed

RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy

Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such...
Authors: Coughlin CM, Vance BA, Grupp SA and Vonderheide RH
SST Peer Reviewed

Marlin-1 a novel RNA binding protein associates with GABA(subB) receptors

GABA(subB) receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the CNS. While heterodimerization between GABA(subB) receptor GABA(subB)R1 and GABA(subB)R2 subunits is essential for functional expression,...
Authors: Couve A, Restituito S, Brandon JM, Charles KJ, Bawagan H, Freeman KB, Pangalos MN, Calver AR and...

CD154 transcriptional regulation in primary human CD4 T cells

CD154 (CD40-ligand) has a wide variety of pleiotropic effects throughout the immune system and is critical to both cellular and humoral immunity. Cell surface and soluble CD154 are primarily expressed by activated CD4 T cells. Expression of CD154 is...
Authors: Cron RQ

Rapid and efficient electroporation-based gene transfer into primary dissociated neurons

Non-viral gene transfer into neurons has proved to be a formidable task. Here, we describe an electroporation-based method that allows efficient and reliable DNA transfer into dissociated neural cells before they are plated and cultured. In...
Authors: Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M and Dityatev A
SST Peer Reviewed

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

CD4+ T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter....
Authors: Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G and Sallusto F

Downregulation of TGFbeta isoforms and their receptors contributes to keratinocyte hyperproliferation in psoriasis vulgaris

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory disorder characterized by epidermal hyperproliferation. Transforming growth factor beta (TGFbetas) have a major antiproliferative action in epidermis. OBJECTIVE: We evaluated the distribution...
Authors: Doi H, Shibata MA, Kiyokane K and Otsuki Y

Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors

Daily alphavbeta5 integrin-dependent phagocytosis of spent photoreceptor outer segment fragments by the retinal pigment epithelium (RPE) is critical for retinal function. This study identifies a key role for focal adhesion kinase (FAK) in RPE...
Authors: Finnemann SC
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