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4536 results sorted by

Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling

BACKGROUND: The molecular reorganization of signaling molecules after T cell receptor (TCR) activation is accompanied by polymerization of actin at the site of contact between a T cell and an antigen-presenting cell (APC), as well as extension of...
Authors: Zipfel PA, Bunnell SC, Witherow DS, Gu JJ, Chislock EM, Ring C, Pendergast AM

Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines

The release of monoamine neurotransmitters from cell bodies and dendrites has an important role in behavior, but the mechanism (vesicular or non vesicular) has remained unclear. Because the location of vesicular monoamine transporter 2 (VMAT2)...
Authors: Li H, Waites CL, Staal RG, Dobryy Y, Park J, Sulzer DL, Edwards RH

Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death

Acid-sensing ion channels (ASICs) composed of ASIC1a subunit exhibit a high Ca(2+) permeability and play important roles in synaptic plasticity and acid-induced cell death. Here, we show that ischemia enhances ASIC currents through the...
Authors: Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, Xu TL

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the genetic program governing CD25(+)CD4(+) regulatory T cell (TR) development and function in mice. In humans, its role in mediating TR development has been...
Authors: Gavin MA, Torgerson TR, Houston E, Deroos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD,...

Atherosclerotic Plaque Macrophage Transcriptional Regulators Are Expressed in Blood and Modulated by Tristetraprolin

Circulating monocytes and plaque macrophages mediate inflammation in the pathogenesis of atherosclerosis. We purified these cells from patients undergoing carotid endarterectomy for advanced atherosclerosis and examined their in vivo transcriptomes...
Authors: Patino WD, Kang JG, Matoba S, Mian OY, Gochuico BR, Hwang PM

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or nonhomologous end joining...
Authors: Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A,...

HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro

We report a novel mechanism, involving up-regulation of the interleukin (IL)-7 cytokine receptor, by which human immunodeficiency virus (HIV) enhances its own production in monocyte-derived macrophages (MDM) in vitro. HIV-1 infection or treatment of...
Authors: Zhang M, Drenkow J, Lankford CS, Frucht DM, Rabin RL, Gingeras TR, Venkateshan C, Schwartzkopff F,...

Upregulation and activation of PKCalpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKCalpha and Src inhibitors

Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive. alpha-Isozyme of protein kinase C (PKCalpha), which is involved in cancer development and progression, has been suggested to be...
Authors: Tan M, Li P, Sun M, Yin G, Yu D

Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage

One of the hallmarks of human immunodeficiency virus (HIV)-1 associated pathology in the CNS is deterioration of neuronal processes. Although there is mounting evidence of neuronal toxicity and cell death induced by the HIV-1 transactivating factor...
Authors: Aprea S, Del Valle L, Mameli G, Sawaya BE, Khalili K, Peruzzi F

Rotavirus spike protein VP4 binds to and remodels actin bundles of the epithelial brush border into actin bodies

We demonstrate here that VP4, a rotaviral protein, is able to specifically bind to bundled actin microfilaments that are subsequently profoundly remodeled into actin bodies. These cytoplasmic actin bodies do not localize within identified...
Authors: Gardet A, Breton M, Fontanges P, Trugnan G, Chwetzoff S
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