Mononuclear, bone marrow, human

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Bone marrow mononuclear cells (common abbreviations: BMNC, BM MNC, and BM-MNC) are a mixed population of single nucleus cells including monocytes, lymphocytes, and hematopoietic stem and progenitor cells.

Cell Type:
Blood/Bone Marrow SC
Tissue Origin:
bone marrow
Species:
human
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Research Area:
Immunotherapy / Hematology
Cell Characteristics:
Suspension

Recommended Media

Lymphocyte Growth Medium-3
LGM-3 is a serum-free medium for lymphocyte and dendritic cell growth

Transfection Information

In case no data are shown for the selected cell type, please take a look at our optimization strategy or contact our Scientific Support Teams to get further guidance on how to easily determine optimal Nucleofection conditions yourself.

Citations (42)

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Barter MJ, Tselepi M, Gómez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA. 
In:
Stem Cells (2015) 33(1): 3266-3280 
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia
Categories:
Primary Cells and Media 
Authors:
Watson AS, Riffelmacher T, Stranks A, Williams O, De Boer J, Cain K, MacFarlane M, McGouran J, Kessler B, Khandwala S, Chowdhury O, Puleston D, Phadwal K, Mortensen M, Ferguson D, Soilleux E, Woll P, Jacobsen SEW, Simon AK 
In:
Cell Death Dis. (2015) 15008 (2015): ePub 
Establishing criteria for human mesenchymal stem cell potency.
Categories:
Primary Cells and Media 
Authors:
Samsonraj RM, Rai B, Sathiyanathan P, Puan KJ, Rötzschke O, Hui JH, Raghunath M, Stanton LW, Nurcombe V, Cool SM 
In:
Stem Cells (2015) 33(6): 1879-91 
Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces.
Categories:
Primary Cells and Media 
Authors:
Hartrianti P, Ling L, Goh LM, Ow KS, Samsonraj RM, Sow WT, Wang S, Nurcombe V, Cool SM, Ng KW 
In:
Stem Cells (2015) ePub: ePub 
Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations.
Categories:
Primary Cells and Media 
Authors:
Salci KR, Lee JH, Laronde S, Dingwall S, Kushwah R, Fiebig-Comyn A, Leber B, Foley R, Dal Cin A, Bhatia M 
In:
Stem Cells (2015) 33(6): 1839-49 
Therapeutic potential of ixmyelocel-T, an expanded autologous multicellular therapy for treatment of ischemic cardiovascular diseases.
Categories:
 
Authors:
Ledford KJ, Murphy N, Zeigler F, Bartel RL, Tubo R 
In:
Stem Cell Res Ther (2015) 6(25): 1-14 
Human CD38hiCD138? plasma cells can be generated in vitro from CD40-activated switched-memory B lymphocytes.
Categories:
Primary Cells and Media 
Authors:
Maïga RI, Bonnaure G, Rochette JT, Néron S 
In:
J Immunol (2014) ePub: ePub 
Characterization of the CD14++CD16+ monocyte population in human bone marrow.
Categories:
Primary Cells and Media 
Authors:
Mandl M, Schmitz S, Weber C, Hristov M 
In:
PLoS ONE (2014) 9(11): ePub 
Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Seeger FH, Rasper T, Fischer A, Muhly-Reinholz M, Hergenreider E, Leistner DM, Sommer K, Manavski Y, Henschler R, Chavakis E, Assmus B, Zeiher AM, Dimmeler S 
In:
Circ Res (2014) 111(7): 854-862 
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.
Categories:
Primary Cells and Media 
Authors:
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR, Kusunoki Y 
In:
J Immunol (2014) 192(12): 5749-60 
Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells.
Categories:
Primary Cells and Media 
Authors:
Terai S, Takami T, Yamamoto N, Fujisawa K, Ishikawa T, Urata Y, Tanimoto H, Iwamoto T, Mizunaga Y, Matsuda T, Oono T, Marumoto M, Burganova G, Fernando Quintanilha L, Hidaka I, Marumoto Y, Saeki I, Uchida K, Yamasaki T, Tani K, Taura Y, Fujii Y, Nishina H, Okita K, Sakaida I 
In:
Tissue Eng (2014) 20(3): 206-10 
Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis.
Categories:
Primary Cells and Media 
Authors:
Keats EC, Dominguez JM, Grant MB, Khan ZA 
In:
Stem Cells (2014) 32(6): 1649-60 
Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.
Categories:
Primary Cells and Media 
Authors:
Agarwal A, MacKenzie RJ, Pippa R, Eide CA, Oddo J, Tyner JW, Sears R, Vitek MP, Odero MD, Christensen DJ, Druker BJ 
In:
Clin Cancer Res (2014) 20(8): 2092-103 
Distinct functional programming of human fetal and adult monocytes.
Categories:
Primary Cells and Media 
Authors:
Krow-Lucal ER, Kim CC, Burt TD, McCune JM 
In:
Blood (2014) 123(12): 1897-904 
Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.
Categories:
Primary Cells and Media 
Authors:
Elman JS, Murray RC, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R4, Parekkadan B 
In:
PLoS ONE (2014) 9(2): ePub 
Loss of quiescence and impaired function of CD34(+)/CD38(low) cells one year following autologous stem cell transplantation
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Woolthuis CM, Brouwers-Vos AZ, Huls G, de Wolf JT, Schuringa JJ, Vellenga E 
In:
Haematologica (2013) 98(12): 1964-71 
Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
Categories:
Primary Cells and Media 
Authors:
He W, Mazumder A, Wilder T, Cronstein BN 
In:
FASEB J (2013) 27(9): 3446-54 
Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fibrotic response in diabetic hearts
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kishore R, Verma SK, Mackie AR, Vaughan EE, Abramova TV, Aiko I, Krishnamurthy P 
In:
PLoS ONE (2013) 8(4): e60161 
Analyses of the combination of 6-MP and dasatinib in cell culture.
Categories:
Primary Cells and Media, Electrophoreses and Analysis  
Authors:
Kaur G, Behrsing H, Parchment RE, Millin MD, Teicher BA. 
In:
Int J Oncol. (2013) 43(1): 13-22 
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells
Categories:
Primary Cells and Media 
Authors:
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Imai K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR, Kusunoki Y. 
In:
J Immunol (2013) 190(12): 6164-72 
Extending human hematopoietic stem cell survival in vitro with adipocytes.
Categories:
 
Authors:
Glettig DL, Kaplan DL. 
In:
BioResearch Open Access (2013) 2(3): 179-85 
PKCd is required for Jagged-1 induction of human mesenchymal stem cell osteogenic differentiation.
Categories:
Primary Cells and Media 
Authors:
Zhu F, Sweetwyne MT, Hankenson KD. 
In:
Stem Cells (2013) 31(6): 1181-92 
Elevated T-box 2 in infantile hemangioma stem cells maintains an adipogenic differentiation-competent state.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Todorovich SM, Khan ZA 
In:
Other (2013) 5(3): 352-7 
Evidence of a Hematopoietic Origin of Human Bone Marrow Stromal Cells
Categories:
Primary Cells and Media 
Authors:
Milwid JM, Li M,USA LeeM J, Yarmush ML, Parekkadan B 
In:
Other (2013) 1(2): 1000113 
The Stabilization Effect of Mesenchymal Stem Cells on the Formation of Microvascular Networks in a Microfluidic Device
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yamamoto K, Tanimura K, Mabuchi Y, Matsuzaki Y, Chung S, Kamm RD, Ikeda M, Tanishita K, Sudo R 
In:
Other (2013) 8(2): 114-128 
Differential Release of Heterogeneous Human Mesenchymal Stem Cell Populations from Haemarthrotic Traumatic Knee Injury
Categories:
 
Authors:
David J. Deehan1,2, Daniel J. Dowen2, Andrew P. Sprowson, Linda C. Ferguson, Nilendran S. Prathalingam, John D. Isaacs1, Mark A. Birch, Rachel A. Oldershaw 
In:
Am J Stem Cell Res (2012) 1(1): 1-8 
Impact of age on the efficacy of bone marrow mononuclear cell transplantation in experimental stroke.
Categories:
Primary Cells and Media 
Authors:
Wagner DC, Bojko M, Peters M, Lorenz M, Voigt C, Kaminski A, Hasenclever D, Scholz M, Kranz A, Weise G, Boltze J. 
In:
Other (2012) 4(1): 17 
Density gradient centrifugation compromises bone marrow mononuclear cell yield.
Categories:
Primary Cells and Media 
Authors:
Pösel C, Möller K, Fröhlich W, Schulz I, Boltze J, Wagner DC. 
In:
PLoS ONE (2012) 7(12): e50293 
Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Allen P, Melero-Martin J, Bischoff J. 
In:
Other (2011) 5(4): 74-86 
Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention.
Categories:
Primary Cells and Media 
Authors:
Fuhler GM, Diks SH, Peppelenbosch MP, Kerr WG. 
In:
Mol Med (2011) 17(7-8): 790-8 
Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.
Categories:
Transfection 
Authors:
Chou BK, Mali P, Huang X, Ye Z, Dowey SN, Resar LM, Zou C, Zhang YA, Tong J, Cheng L. 
In:
Cell Res (2011) 21: 518-529 
Differential expression of microRNAs in CD34+ cells of 5q- syndrome
Categories:
Primary Cells and Media 
Authors:
Votavova H, Grmanova M, Dostalova Merkerova M, Belickova M, Vasikova A, Neuwirtova R, Cermak J 
In:
J Hematol Oncol (2011) 6(4): 1 
The effect of transcatheter injections on cell viability and cytokine release of mononuclear cells.
Categories:
Primary Cells and Media 
Authors:
El Khoury R, Misra V, Sharma S, Cox CS, Walker P, Grotta JC, Gee A, Suzuki S, Savitz SI. 
In:
Other (2010) 31(8): 1488-92 
Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.
Categories:
Primary Cells and Media, Electrophoreses and Analysis  
Authors:
Sittichokechaiwut A1, Edwards JH, Scutt AM, Reilly GC 
In:
Other (2010) 20: 45-57 
Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5
Categories:
Primary Cells and Media 
Authors:
Walter K, Cockerill PN, Barlow R, Clarke D, Hoogenkamp M, Follows GA, Richards SJ, Cullen MJ, Bonifer C, Tagoh H. 
In:
Oncogene (2010) 29(20): 2927-37 
Percutaneous cell delivery into the heart using hydrogels polymerizing in situ.
Categories:
Primary Cells and Media 
Authors:
Martens TP, Godier AF, Parks JJ, Wan LQ, Koeckert MS, Eng GM, Hudson BI, Sherman W, Vunjak-Novakovic G 
In:
Cell Transplant (2009) 18(2): 297-304 
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.
Categories:
Primary Cells and Media 
Authors:
Scarfì S, Fresia C, Ferraris C, Bruzzone S, Fruscione F, Usai C, Benvenuto F, Magnone M, Podestà M, Sturla L, Guida L, Albanesi E, Damonte G, Salis A, De Flora A, Zocchi E. 
In:
Stem Cells (2009) 27(10): 2469-77 
Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
van Beem RT, Verloop RE, Kleijer M, Noort WA, Loof N, Koolwijk P, van der Schoot CE, van Hinsbergh VW, Zwaginga JJ. 
In:
J Thromb Haemost (2009) 7(1): 217-226 
Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner.
Categories:
Primary Cells and Media 
Authors:
Hartmann TN, Leick M, Ewers S, Diefenbacher A, Schraufstatter I, Honczarenko M, Burger M. 
In:
Immunology (2008) 125(2): 252-62 
Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture.
Categories:
Primary Cells and Media 
Authors:
Mifune Y, Matsumoto T, Kawamoto A, Kuroda R, Shoji T, Iwasaki H, Kwon SM, Miwa M, Kurosaka M, Asahara T 
In:
Stem Cells (2008) 26(6): 1395-405 
Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Murdoch AD, Grady LM, Ablett MP, Katopodi T, Meadows RS, Hardingham TE 
In:
Stem Cells (2007) 25(11): 2786-96 
Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural.
Categories:
Primary Cells and Media 
Authors:
Chen N, Hudson JE, Walczak P, Misiuta I, Garbuzova-Davis S, Jiang L, Sanchez-Ramos J, Sanberg PR, Zigova T, Willing AE. 
In:
Stem Cells (2005) 23(10): 1560-70 
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